Melmed S., Polonsky K.S. Williams Textbook of Endocrinology

12th ed. — Saunders: Elsevier, 2011. — 1816 p.Welcome to the twelfth edition of Williams Textbook of Endocrinology.
Robert Williams inaugurated this enduring textbook more than 50 years ago, and the goals have remained essentially unchanged (i.e., to publish a condensed and authoritative discussion of the management of clinical endocrinopathies based upon the application of fundamental information obtained from chemical and physiological investigation). Of course, today we would add results of cellular and genomic investigation, as well as the wealth of clinical trial data, as aids in clinical management. The immense and often overwhelming body of new information from multiple disciplines, in fact, makes this synthetic endeavor more relevant than ever to help guide endocrinologists in the care of their patients. To encourage the goal of both highest quality scientific rigor and knowledge synthesis, we continue to ask the most distinguished authors to synthesize entire areas of clinical endocrine science. The mandate for concise yet authoritative and comprehensive presentations acknowledges both the time pressures on today’s physicians and the desire to make the text affordable and easily navigated.
This edition has involved extensive revisions of the previous text, and 22 new authors have joined our expert faculty. A uniform style facilitates identification and ready use of clinical algorithms.
We express our deep gratitude to the co-workers in our offices: Anita Nichols, Lynn Moulton, Grace Labrado, Louise Ishibashi, and Sherri Turner, whose energetic efforts have made this work possible. We also thank our colleagues at Elsevier—Joan Ryan, Pamela Hetherington, and Dolores Meloni—who skillfully navigated the dynamic world of medical publishing while assuring achievement of our goals. Their efforts have been essential in ensuring the successful publication of this high-quality textbook, which has become the classic text for all professionals engaged in caring for patients with endocrine disorders.
Finally, we would like to recognize and congratulate Dr. Melvin Grumbach for his outstanding contributions to Williams Textbook of Endocrinology, beginning with the fourth edition that was published in 1968.Contents:
Hormones and Hormone Action.
Principles of Endocrinology.
The Endocrine Patient.
Genetic Control of Peptide Hormone Formation.
Mechanism of Action of Hormones that Act on Nuclear Receptors.
Mechanism of Action of Hormones that Act at the Cell Surface.
Laboratory Techniques for Recognition of Endocrine Disorders.
Hypothalamus and Pituitary.
Neuroendocrinology.
Pituitary Physiology and Diagnostic Evaluation.
Pituitary Disorders.
Posterior Pituitary.
Thyroid.
Thyroid Physiology and Diagnostic Evaluation of Patients with Thyroid Disorders.
Thyrotoxicosis.
Hypothyroidism and Thyroiditis.
Nontoxic Diffuse and Nodular Goiter and Thyroid Neoplasia.
Adrenal Cortex and Endocrine Hypertension.
The Adrenal Cortex.
Endocrine Hypertension.
Reproduction.
The Physiology and Pathology of the Female Reproductive Axis.
Hormonal Contraception.
Testicular Disorders.
Sexual Dysfunction in Men and Women.
Endocrinology and the Life Span.
Endocrine Changes in Pregnancy.
Endocrinology of Fetal Development.
Disorders of Sex Development.
Normal and Aberrant Growth.
Puberty: Ontogeny, Neuroendocrinology, Physiology, and Disorders.
Hormones and Athletic Performance.
Endocrinology and Aging.
Mineral Metabolism.
Hormones and Disorders of Mineral Metabolism.
Metabolic Bone Disease.
Kidney Stones.
Disorders of Carbohydrates and Metabolism.
Type 2 Diabetes Mellitus.
Type 1 Diabetes.
Complications of Diabetes Mellitus.
Glucose Homeostasis and Hypoglycemia.
Body Fat and Lipid Metabolism.
Neuroendocrine Control of Energy Stores.
Obesity.
Disorders of Lipid Metabolism.
Endocrinology of HIV/AIDS.
Gastrointestinal Hormones and Gut Endocrine Tumors.
Polyendocrine and Neoplastic Disorders.
Pathogenesis of Endocrine Tumors.
Multiple Endocrine Neoplasia.
The Immunoendocrinopathy Syndromes.
Endocrine Management of the Cancer Survivor (title changed).
Carcinoid Tumors, Carcinoid Syndrome and Related Disorders.