Connors K.A. Thermodynamics of Pharmaceutical Systems: An Introduction for Students of Pharmacy

Wiley, 2002. — 344 p.The pharmaceutical sciences have always struggled with the varied backgrounds of a diverse student population and in most cases background material in either the physical chemical or biological sciences, is desirable depending upon their undergraduate backgrounds. With the increasingly biological orientation of the pharmaceutical sciences a large number of incoming students have not had the basics of physical chemistry or thermodynamics which are fundamental to drug discovery, design and understanding mechanism of transport and action in the body. In addition, the industry as well as the Food and Drug Administration through its Critical Path initiative express an urgent need to move towards much scientific orientation of formulation and manufacture to try to reduce the extensive time needed to develop, test and eventually market a drug often due to historic trial and error processes based upon previously approved processes. This textbook could fill that void nicely in many graduate programs and lay the foundation for higher level courses.Energy and the First Law of Thermodynamics
The Entropy Concept
The Free Energy
Equilibrium
Introduction to Physical Processes
Phase Transformations
Solutions of Nonelectrolytes
Solutions of Electrolytes
Colligative Properties
Solubility
Surfaces and Interfaces
Acid-Base Equilibria
Electrical Work
Noncovalent Binding Equilibria
Appendices
Answers to Problems