Zhuo Min. Chronic Pain: New Molecular Insights Into Pain and Treatment

World Scientific Publishing, 2024. — 341 p. — ISBN 978-981-4324-52-6.This book successfully explores cellular and molecular mechanisms of chronic pain based on recent basic neurobiological investigations. By focusing on major breakthroughs in basic neurosciences, it is believed to contain the promise for future new pain drug discovery. Instead of repeating extensive reviews of basic animal and clinical observations, the book provides a novel neuronal model that is believed to be the key target for treating chronic pain. In addition, it reviews and validates animal models developed for studying basic mechanisms of pain and chronic pain, and the current medicine used to treat chronic pain as well as alternative pain treatment. The final few chapters also cover how pain may interfere with other high brain functions, such as fear, anxiety, sleep, memory, etc.Introduction
Basic Neurosciences and Pain
Peripheral Nociceptors and Sensitization
Spinal Dorsal Horn Synaptic Transmission and Gate Theory
Silent Synapse
Cortical LTP
Cortical Depression
Cortical Sensitization and Reorganization
NMDA NR2B
Pain and Fear
Pain and Anxiety
Descending Pain Facilitation
Current Drug and Novel Drug Target for Treating Chronic Pain