Malhotra G.K. Active Pharmaceutical Ingredient Manufacturing: Nondestructive Creation

Walter de Gruyter GmbH, 2022. — 331 p. — ISBN: 978-3-11-070282-8. — De Gruyter STEM Series.The book reviews the history of current brand and generic business in pharmaceuticals manufacturing practices. Based on examples, the reader can interpolate, extrapolate and exploit mutual behavior (physical and chemical properties) of chemicals to design and commercialize processes that fulfi ll the demands, also manipulate chemical unit processes and unit operations to reduce/minimize effl uents and lower environmental impact i.e. reduce global warming. Readers will be able to simplify process development, design and commercialize economic manufacturing processes.
Of interest to fine and specialty chemicals, including active pharmaceutical ingredients, additives for plastics, coatings, flavor, fragrance, and food industry.
With examples of processes that could be commercialized to produce API continuously.History of pharmaceuticals
Business model: brand versus generics, product demand, process selection, and economics
Physical and chemical properties
Pharma chemistry/chemical development
Manufacturing process development and case studies
Active pharmaceutical ingredients (API): innovation, design considerations, and waste reduction
Process documentation and operating strategies
Road Map