Tappia Paramjit S., Ramjiawan B., Dhalla N.S. (eds.) Cellular and Biochemical Mechanisms of Obesity

Springer, 2021. — 1145 p. — (Advances in Biochemistry in Health and Disease). — ISBN 978-3-030-84763-0.Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.Pathophysiologic Mechanisms of Obesity
Obesity as a Major Health Hazard
Endocrine Role of Adipose Tissue in Obesity and Related Disorders
Interaction Between Genetics and Epigenetics in Obesity and Their Clinical Significance
The Epigenetics and Molecular Interplay in Obesity and Associated Complications
Cellular and Biochemical Mechanisms Driving the Susceptibility of Obese Subjects to Covid-19 Infection
Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases:​ Role of Ion Channels
Hypothalamus-Mediated Actions in the Genesis of Obesity
Cellular and Molecular Effects of Obesity on the Heart
Dietary Advanced Glycation End Products as Mediators of Obesity:​ Cellular and Molecular Mechanisms of Action
Monoamine Oxidase, Obesity and Related Comorbidities:​ Discovering Bonds
Adipose Extracellular Matrix Remodeling in Obesity and Insulin Resistance
Therapeutic Mechanisms of Obesity
Obesity; Its Prevalence, Consequences and Potential Therapies
Obesity:​ Molecular Mechanisms, Epidemiology, Complications and Pharmacotherapy
Telomere Shortening and Calorie Restriction in Obesity
Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions
The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases
New Therapeutic Agents in Obesity-Related Cardiovascular Disorders:​ Molecular and Cellular Insights
Role of the Synchronization of Circadian Clock by Meal-Timing in Obesity and Type 2 Diabetes
Methylglyoxal and Its Role in Obesity-Associated Heart Failure with Preserved Ejection Fraction
Marine Derived Bioactives to Combat Obesity:​ Potential Mechanisms of Action
Bitter Melon in Combination with Diet Modification and Regular Exercise Can Prevent and Treat Obesity and Hypertension Cost-Effectively