Jasani Bharat, Huss Ralf, Taylor Clive R. Precision Cancer Medicine: Role of the Pathologist

Springer, 2021. — 239 p. — ISBN 978-3-030-84086-0.This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.The Evolution of Pathology and Precision Medicine
Introduction: From ‘Tissue Diagnosis’ to Biomarkers
The Advent of Biomarker Testing
The Practical Challenges for Pathology: Multiple Rapidly Evolving Methods
Precision Medicine Demands Precision Pathology
Evolution of the Total Test Approach to Tissue Based Pathological Analysis
Pre-Analytic Phase: Test Selection; Specimen Acquisition and Handling
Pre-Analytic Phase: Specimen Type and Acquisition
Pre-Analytical Phase: Biopsy/Tissue Handling and Processing
Analytical Phase: Protocol and Antigen Retrieval
Analytical Phase: Principles for Immunohistochemistry (IHC)
Analytical Phase: Current Controls; Fit for Purpose Selection and Validation
Analytical Phase: Alternative and New Control Systems
Post-Analytic Phase: Interpretation, Scoring and Reporting of Biopsy Results
Description and Interpretation of Results; The Pathology Report
Immunofluorescence, In Situ Hybridization and Alternative Forms of ‘Labeled’ Microscopy
Role of the Pathologist in Predictive Biomarker Analysis
Implementation of Precision Cancer Diagnostic Test
Role of Pathologist in Precision Cancer Diagnosis
Digital and Computational Pathology and Their Role in Precision Oncology
Introduction to Digital and Computational Pathology
AI in the Pre-Analytical Phase
AI in the Analytical Phase
AI in the Post-Analytical Phase
AI in the Decision Phase