Maiese Kenneth (ed.) Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery

Academic Press, 2021. — 281 p. — ISBN 978-0-12-822467-0.Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.Sirtuins and metabolic disease
Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide
Sirtuins in metabolic and epigenetic regulation of stem cells
Sirtuins and metabolic regulation: food and supplementation
Sirtuins in diabetes mellitus and diabetic kidney disease
Sirtuins and mitochondrial dysfunction
Sirtuins in immunometabolism
Mitochondrial sirtuins at the crossroads of energy metabolism and oncogenic transformation
Sirtuins and cancer
Sirtuins and the hallmarks of cancer
The bifunctional roles of sirtuins and their therapeutic potential in cancer
Sirtuins and next generation hallmarks of cancer: cellular energetics and tumor promoting inflammation
Sirtuins and cellular metabolism in cancers
Dual role of sirtuins in cancer
Sirtuin signaling in hematologic malignancies
Impacts of sirtuin1 and sirtuin3 on oral carcinogenesis