Lai Kar Neng (ed.) Recent Advances in Iga Nephropathy

World Scientific Publishing, 2009. — 440 p. — ISBN 978-981-283-586-4.IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.IgA Nephropathy: Discovery of a Distinct Glomerular Disorder
Epidemiology and Ancestral Difference
Genetic Contribution of IgA Nephropathy
Histopathology, Immunofluorescence and Ultrastructural Examination
Tubulointerstitial Injury in IgA Nephropathy
Podocyte Pathology
Clinicopathologic Findings
Clinical Course of Primary IgA Nephropathy
Special Clinical Syndromes
IgA Nephropathy in Children
Recurrent IgA Nephropathy in Transplant
IgA Molecule
IgA Immune-Complex
B and T Lymphocytes
IgA Receptors and Mesangial IgA Deposition
Antigen-Dependent Mechanism of IgA Nephropathy
Complement Activation
Cytokines and Growth Factors
Leukocytes, Macrophages and Monocytes
Renin-Angiotensin System
Corticosteroids
Treatment for IgA Nephropathy: Renin-Angiotensin Blockade
Other Immunomodulatory Agents
Other Non-Immunomodulatory Agents
Treatment of IgA Nephropathy: Tonsillectomy
Experimental Model of IgA Nephropathy
Future Prospect for IgA Nephropathy