Shapiro Jay R., Byers Peter H. et. al. (eds.) Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease

Academic Press, 2014. — 2367 p. — ISBN: 9780123977892.Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.Bone Biology, Structure and Biochemistry
Clinical and Molecular Genetics of Osteogenesis Imperfecta
COL1A1 and COL1A2 Mutations
Animal Models of Osteogenesis Imperfecta
Brittle Bone Overlap Phenotypes: TGF-Beta Mutations and Bone
Clinical Aspects of Osteogenesis Imperfecta
Organ Involvement in Osteogenesis Imperfecta
Orthopedics
Physical Medicine and Rehabilitation
Pharmacologic Treatment of Osteogenesis Imperfecta
Genetic Approach to Treatment of Osteogenesis Imperfecta