Kulikov K., Koshlan T. Laser Interaction with Heterogeneous Biological Tissue: Mathematical Modeling

2nd Edition. — Springer, 2018. — 197 p. — (Biological and Medical Physics, Biomedical Engineering). — ISBN: 3319941135.This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin.
In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells.Methods Describing the Interaction of Laser Radiation with Biological Tissues
Overview of Theoretical Approaches to the Analysis of Light Scattering
Study of Electrophysical Characteristics of Blood Formed Elements Using Intracavity Laser Spectroscopy
Mathematical Models of the Interaction of Laser Radiation with Turbid Media
Study of the Optical Characteristics of a Biotissue with Large-Scale Inhomogeneities
Light Scattering by Dielectric Bodies of Irregular Shape in a Layered Medium
Modeling of the Optical Characteristics Fibrillar Structure
Theoretical Determination the Function of Size Distribution for Blood Cells
Study of Optical Properties of Biotissues by the Intracavity Laser Spectroscopy Method
Study of the Optical Characteristics of Thin Layer of the Biological Sample
Simulation of the Thermal Processes
Determination of the Optical Parameters on the Basis of Spectrophotometric Data