Cronin M.T.D., Madden J.C., Enoch S.J., Roberts D.W. Chemical Toxicity Prediciton: Category Formation and Read-Across

The Royal Society of Chemistry, UK, 2013. — 204 p. — (Issues in Toxicology No.17) — ISBN: 1849733848The aim of this book is to provide the scientific background to using the formation of chemical categories, or groups, of molecules to allow for read-across i.e. the prediction of toxicity from chemical structure. It covers the scientific basis for this approach to toxicity prediction including the methods to group compounds (structural analogues and / or similarity, mechanism of action) and the tools to achieve this.An Introduction to Chemical Grouping, Categories and Read-Across to Predict Toxicity
Approaches for Grouping Chemicals into Categories
Informing Chemical Categories through the Development of Adverse Outcome Pathways
Tools for Grouping Chemicals and Forming Categories
Sources of Chemical Information, Toxicity Data and Assessment of Their Quality
Category Formation Case Studies
Evaluation of Categories and Read-Across for Toxicity Prediction Allowing for Regulatory Acceptance
The State of the Art and Future Directions of Category Formation and Read-Across for Toxicity Prediction