Dobrovolskaia M.A., McNeil S.E. (Eds.) Handbook of Immunological Properties of Engineered Nanomaterials (Frontiers in Nano Biomedical Research. Volume 1)

World Scientific Publishing Co. Pte. Ltd., 2013. – 721 p. – ISBN: 9789814390255"The Handbook of Immunological Properties of Engineering Nanomaterials" provides a comprehensive overview of current literature, methodologies, translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is immunological properties of engineered nanomaterials. The focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, Dendritic cells, complement and coagulation systems, interaction with plasma proteins, nanoparticle sterility and sterilization. Each chapter includes a comprehensive literature review of a given area; describes protocols and resources available to support research in individual focus area; highlights challenges; and outlines unanswered questions and future directions. In addition, the handbook provides an overview and a practical guide to physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. The handbook also reviews regulations related to immunotoxicity testing of materials prior to their translation into clinic. It is written by top experts in the field of nanomedicine, nanotechnology and translational bionanotechnology representing academia, government, industry, consulting organizations and regulatory agencies. The handbook is designed to serve as a textbook for students, a practical guide for research laboratories and an informational resource for scientific consultants, reviewers and policy makers. It is written such that both experts and beginners will find useful information.Immunological Properties of Engineered Nanomaterials: An Introduction
Importance of Physicochemical Characterization Prior to Immunological Studies
Impact of Nanoparticle Sterilization on Analytical Characterization
Endotoxin and Engineered Nanomaterials
Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory
and Toxicological Processing
Nanoparticle Interaction with Plasma Proteins as It Relates to Biodistribution
The Effects of Engineered Nanomaterials on Erythrocytes
The Effects of Engineered Nanomaterials on Cultured Endothelial Cells
The Effect of Engineered Nanomaterials on the Plasma Coagulation System
The Effects of Engineered Nanomaterials on Platelets
Complement Activation
Bidirectional Interaction Between Nanoparticles and Cells of the Mononuclear Phagocytic System
The Effects of Nanoparticles on Dendritic Cells
The Effects of Nanoparticles on Bone Marrow Cells
Nanoparticles, Immunomodulation and Vaccine Delivery
Nanoparticles as Drug Delivery Vehicles for the Therapy of Inflammatory Disorders
Nanostructures and Allergy
Nanoparticles and Antigenicity
In Vitro Assays for Monitoring Nanoparticle Interaction with Components of the Immune System
Evaluating the Adverse Effects of Nanomaterials on the Immune System with Animal Models
Immunotoxicity Testing for Drug–Nanoparticle Conjugates: Regulatory Consideration