Pethig R.R., Smith S. Introduction to bioelectronics: for engineers and physical scientists

Hoboken: Wiley, 2012.
Bioelectronics is a rich field of research involving the application of electronics engineering principles to biology, medicine, and the health sciences. With its interdisciplinary nature, bioelectronics spans state-of-the-art research at the interface between the life sciences, engineering and physical sciences.
Introductory Bioelectronics offers a concise overview of the field and teaches the fundamentals of biochemical, biophysical, electrical, and physiological concepts relevant to bioelectronics. It is the first book to bring together these various topics, and to explain the basic theory and practical applications at an introductory level.
The authors describe and contextualise the science by examining recent research and commercial applications. They also cover the design methods and forms of instrumentation that are required in the application of bioelectronics technology. The result is a unique book with the following key features:
- an interdisciplinary approach, which develops theory through practical examples and clinical applications, and delivers the necessary biological knowledge from an electronic engineer's perspective.
- a problem section in each chapter that readers can use for self-assessment, with model answers given at the end of the book along with references to key scientific publications.
- discussions of new developments in the bioelectronics and biosensors fields, such as microfluidic devices and nanotechnology.
Supplying the tools to succeed, this text is the best resource for engineering and physical sciences students in bioelectronics, biomedical engineering and micro/nano-engineering. Not only that, it is also a resource for researchers without formal training in biology, who are entering PhD programmes or working on industrial projects in these areas.About the Authors.
Foreword.
Preface Acknowledgements.
Basic Chemical and Biochemical Concepts Overview.
Energy and Chemical Reactions.
Water and Hydrogen Bonds.
Acids, Bases and pH.
Summary of Key Concepts.
Cells and their Basic Building Blocks Overview.
Lipids and Biomembranes.
Carbohydrates and Sugars.
Amino Acids, Polypeptides and Proteins.
Nucleotides, Nucleic Acids, DNA, RNA and Genes.
Cells and Pathogenic Bioparticles.
Summary of Key Concepts.
Basic Biophysical Concepts and Methods Overview.
Electrostatic Interactions.
Hydrophobic and Hydration Forces.
Osmolarity, Tonicity and Osmotic Pressure.
Transport of Ions and Molecules across Cell Membranes.
Electrochemical Gradients and Ion Distributions Across Membranes.
Osmotic Properties of Cells.
Probing the Electrical Properties of Cells.
Membrane Equilibrium Potentials.
Nernst Potential and Nernst Equation.
The Equilibrium (Resting) Membrane Potential.
Membrane Action Potential.
Channel Conductance.
The Voltage Clamp.
Patch-Clamp Recording.
Electrokinetic Effects.
Spectroscopic Techniques Overview.Classes of Spectroscopy.
The Beer-Lambert Law.
Impedance Spectroscopy.
Electrochemical Principles and Electrode Reactions Overview.Electrochemical Cells and Electrode Reactions.
Electrical Control of Electron Transfer Reactions.
Reference Electrodes.
Electrochemical Impedance Spectroscopy (EIS).
Biosensors Overview.Immobilisation of the Biosensing Agent.
Biosensor Parameters.
Amperometric Biosensors.
Potentiometric Biosensors.
Conductometric and Impedimetric Biosensors.
Sensors Based on Antibody Antigen Interaction.
Photometric Biosensors.
Biomimetic Sensors.
Glucose Sensors.
Biocompatibility of Implantable Sensors.
Basic Sensor Instrumentation and Electrochemical Sensor Interfaces Overview.
Transducer Basics.
Sensor Amplification.
The Operational Amplifier.
Limitations of Operational Amplifiers.
Instrumentation for Electrochemical Sensors.
Impedance Based Biosensors.
FET Based Biosensors.
Instrumentation for Other Sensor Technologies Overview.
Temperature Sensors and Instrumentation.
Mechanical Sensor Interfaces.
Optical Biosensor Technology.
Transducer Technology for Neuroscience and Medicine.
Microfluidics: Basic Physics and Concepts Overview.
Liquids and Gases.
Fluids Treated as a Continuum.
Basic Fluidics.
Fluid Dynamics.
Navier-Stokes Equations.
Continuum versus Molecular Model.
Diffusion.
Surface Tension.
Microfluidics: Dimensional Analysis and Scaling Overview.
Dimensional Analysis.
Dimensionless Parameters.
Applying Nondimensional Parameters to Practical Flow Problems.
Characteristic Time Scales.
Applying Micro- and Nano-Physics to the Design of Microdevices.
Problems.Appendix A: SI Prefixes.
Appendix B: Values of Fundamental Physical Constants.
Appendix C: Model Answers for Self-study Problems.