Nakao K., Minato N., Uemoto S. (Ed.) Innovative Medicine. Basic Research and Development

Springer Japan KK, 2015. — 330 p. — ISBN: 978-4-431-55650-3.Despite rapid and remarkable advances in basic medical science, discoveries in basic science can successfully be translated into clinical applications only after a time-consuming process and, unfortunately, only in extremely rare cases. The process has often been likened to a seemingly endless trip through a long and dark tunnel. The research fi eld of translational science has thus been craved for, to unite basic and clinical sciences and make innovative medical technology a reality.
There are multiple vital steps in the creation of innovative medical technology: development and analysis of optimal animal models of human diseases, interpretation of data from genome science and epidemiology to address human disease and pathology, and establishment of “proof of concept” that plays a pivotal role in transitional to preclinical stages of translational science. Besides drug research and development, great expectations have been harbored for progress in diagnostic technology, new surgical procedures, and new clinical devices and equipment. Original research targets may well be rare diseases. More importantly, one can hope and try to expand the scope of the research into common diseases with the aid of “clinical wisdom.”Basic Research for Innovative Medicine
Edouard Mullarky and Lewis C. Cantley Diverting Glycolysis to Combat Oxidative Stress
Sihao Liu, Michael Downes and Ronald M. Evans Metabolic Regulation by Nuclear Receptors
Thorsten Berger, Mary E. Saunders and Tak W. Mak Fighting Fire with Fire in Cancer
Kazuhiro Iwai Linear Polyubiquitination: A Crucial Regulator of NF-κB Activation
Akira Kakizuka VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders
Shin Maeda and Hayato Nakagawa Roles of E-cadherin in Hepatocarcinogenesis
Miki Nishio, Hiroki Goto, Miki Suzuki, Aya Fujimoto, Koshi Mimori and Akira Suzuki The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
Akira Shibuya, Chigusa Nakahashi-Oda and Satoko Tahara-Hanaoka Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation
Wataru Nishie and Hiroshi Shimizu Doxycycline-Inducible Autoimmune Blistering Skin Disease Model
Nagahiro Minato T Cell Senescence and Autoimmunity
Translational Research for Innovative Medicine
Tadamitsu Kishimoto, Sujin Kang and Toshio Tanaka IL-6: A New Era for the Treatment of Autoimmune Infl ammatory Diseases
Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh and Miyako Tanaka Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies
Akira Sawa Multifaceted Translational Approach to Major Mental Illness
Ken Ebihara and Kazuwa Nakao Translational Research of Leptin in Lipodystrophy and Its Related Diseases
Akihiro Yasoda and Kazuwa Nakao Translational Research of the Activation of the C-Type Natriuretic Peptide (CNP)-Guanylyl Cyclase-B Scott L. Friedman Pathway for Skeletal Dysplasia Clarity and Challenges in Tissue Fibrosis
Motohiro Nishida, Koichiro Kuwahara, Daisuke Kozai, Reiko Sakaguchi and Yasuo Mori TRP Channels: Their Function and Potentiality as Drug Targets
Shigeomi Shimizu Autophagic Cell Death and Cancer Chemotherapeutics
Kazuo Kitamura, Shinya Ashizuka, Haruhiko Inatsu and Toshihiro Kita Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis
X. Y. Zhao, J. Voutila, Nagy A. Habib and Vikash Reebye RNA Activation
New Technology for Innovative Medicine
Masaki Ieda Proceedings of the Uehara Memorial Foundation. Innovative Medicine: Basic Research and Development. Cardiac Reprogramming for Heart Repair
Michitaka Ozaki, Takeaki Ozawa and Yuma Yamada Development of a New In Vivo Optical Probe for Biological Diagnosis and Therapy
Shinji Uemoto, Yasuhiro Fujimoto, Takumi Teratani, Hiroyuki Kanazawa, Junji Iwasaki, Zhao Xiangdong, Yuki Masano, Shintaro Yagi, Koichiro Hata and Eiji Kobayashi Introduction of Mesenchymal Stem Cells for Liver Surgery (Hepatectomy and Transplantation)
Yoshikazu Ugawa Synaptic and Axonal Plasticity Induction in the Human Cerebral Cortex
Koichi Akashi TIM-3 Is a Novel Therapeutic Target for Eradicating Acute Myelogenous Leukemia Stem Cells
Mitsuko Hara, Tomokazu Matsuura and Soichi Kojima TGF-β LAP Degradation Products, a Novel Biomarker and Promising Therapeutic Target for Liver Fibrogenesis
Kenichi Horisawa and Atsushi Suzuki Cell-Based Regenerative Therapy for Liver Disease