Mahrwald R. (Ed.) Modern Aldol Reactions: Vol. 1: Enolates, Organocatalysis, Biocatalysis and Natural Product Synthesis

Weinheim: Wiley-VCH. – 2004. – 344 p. Historically, the stimulus for the development of a particular reaction has been interconnected with a class of natural products whose synthesis would be greatly facilitated by the use of that particular bond construction. This two-volume series on aldol addition reaction methodology brings together an up-to-date discussion of all aspects of this versatile process. The reader will gain an appreciation for the role of metal enolate architecture in aldol diastereoselectivities (Vol. I; Chapters 1–3) and addition are surveyed, as is the exciting progress being made in the use of chiral amines as aldol catalysts (Vol. I; Chapter 4). This highly active area of research will continue to develop ever more versatile chiral catalysts and stereochemical control concepts. Students and researchers in the field of asymmetric synthesis will greatly profit from the contributions of this distinguished group of authors who have so insightfully reviewed this topic. ContentsList of Contributors
Fundamentals and Transition-state Models. Aldol Additions of Group 1 and 2 Enolates
The Development of Titanium Enolate-based Aldol Reactions
Boron and Silicon Enolates in Crossed Aldol Reaction
Amine-catalyzed Aldol Reactions
Enzyme-catalyzed Aldol Additions
Antibody-catalyzed Aldol Reactions
The Aldol Reaction in Natural Product Synthesis: The Epothilone Story