National Aeronautics and Space Administration (NASA). This Technical Handbook approved by NASA 06-03-2007. Superseding NASA-STD-(I)-4005. 63 p. The information in this handbook presents an overview of the current understanding of the various plasma interactions that can result when a high-voltage system is operated in the Earth’s ionosphere, references common design practices that have exacerbated plasma interactions in the past, and recommends standard practices to eliminate or mitigate such reactions.