Cho S.H., Krishnan S. (Eds.) Cancer Nanotechnology: Principles and Applications in Radiation Oncology

CRC Press, 2013. — 281 p.Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors - a hallmark of unrestrained growth - results in the passive accumulation of nanoparticles within tumors. Cancer Nanotechnology: Principles and Applications in Radiation Oncology is a compilation of research in the arena of nanoparticles and radiation oncology, which lies at the intersection of disciplines as diverse as clinical radiation oncology, radiation physics and biology, nanotechnology, materials science, and biomedical engineering. The book provides a comprehensive, cross-disciplinary survey of basic principles, research techniques, and outcomes with the goals of eventual clinical translation.
Coverage includes
- A general introduction to fabrication, preferential tumor targeting, and imaging of nanoparticles
- The specific applications of nanomaterials in the realms of radiation therapy, hyperthermia, thermal therapy, and normal tissue protection from radiation exposure
- Outlooks for future research and clinical translation including regulatory issues for ultimate use of nanomaterials in humans
Reflecting profound advances in the application of nanotechnology to radiation oncology, this comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. Along with various computational and experimental techniques, each chapter highlights the most promising approaches to the use of nanoparticles for radiation response modulation.Basic Principles of Radiation Oncology and Radiosensitization
Basic Principles of Radiation Therapy of Cancers
Biological Principles of Radiosensitization
Principles and Application of Hyperthermia Combined with Radiation
Synthesis, Safety, and Imaging of Nanomaterials for Cancer Applications
Synthesis and Surface Modification of Nanomaterials for Tumor Targeting
Safety Concerns for Nanomaterials in Nanomedicinal Applications
Imaging with Nanoparticles
Optical Microscopy of Plasmonic Nanoparticles
X-ray Fluorescence Computed Tomography Imaging of Nanoparticles
Nanomaterials for Radiation Therapy
Gold Nanoparticle–Mediated Radiosensitization
Quantification of Gold Nanoparticle–Mediated Radiation Dose Enhancement
Semiconductor Nanomaterials for Radiotherapy
Radioactive Gold Nanoparticles for Tumor Therapy
Nanoparticles for Selective Radioprotection of Normal Tissues
Nanomaterials for Hyperthermia and Thermal Therapy
Gold Nanoparticle–Mediated Hyperthermia in Cancer Therapy
Magnetic Resonance Temperature Imaging for Gold Nanoparticle–Mediated Thermal Therapy
Modeling of Plasmonic Heat Generation from Gold Nanoparticles
Carbon Nanotubes for Thermal Therapy
Future Outlook
Regulatory Issues for Clinical Translations
Clinical Translations of Nanotechnology: Present and Future Outlook